Rapid-VACC™ DNA vaccine cloning services
Rapid-VACC™ is a cloning service that allows production of new vaccines in a 2-4 week timeframe, in keeping with pandemic response preparedness. The process incorporates rational design (Williams et al., 2009) and proven DNA vaccine backbones (Williams et al., 2006).
Alternatively, NTC also provides vectors and kits for the construction of DNA vaccines:
Options include RIG-1 activating eRNA elements:
And antibiotic-free plasmid DNA backbones with highest copy yielding plasmids (Luke et al., 2009):
References:
Plasmid DNA vaccine vector design: Impact on efficacy, safety and upstream production. Biotechnol. Adv. 27:353-370. Williams, JA, Carnes, AE, Hodgson, CP (2009)
pDNAVACCultra family: High throughput intracellular targeting DNA vaccine plasmids. Vaccine 24:4671-4679Williams, JA, Luke, J, Johnson, L, Hodgson, CP (2006)
Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system. Luke J, Carnes AE, Hodgson CP, Williams JA. Vaccine (2009)
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