Biologics by design

Nature Technology (NTC) is a "one stop shop" for gene therapy industry partners, providing state of the art Technologies and Services that are needed for success in the clinic, and beyond.

Nanoplasmids

Viral Vector Retrofits

DNA Manufacturing

Nanoplasmids, Non-viral vectors

Improved in vivo expression, duration, safety, economy, and ease of use.

 

The Nanoplasmid (less than 500bp) has proven to be an ideal vector for both indirect use (as for viral vector and transposon manufacturing) and for direct use, as an effective, safe, and economical one for gene- and immuno-therapy and manufacturing… (more)

 

 

The “Keystone” to success
 in gene therapy

Nanoplasmids Project Development Timeline

Start to finish: about 4 weeks

 Nanoplasmid™

PDF Brochure

Call NTC today to discuss your projects.

Viral Vector Retrofits

Including: AAV, Lenti, Retrovirus,

Helper Vectors & Transposons

 

NTC’s "antibiotic free" Nanoplasmids are easily substituted for conventional plasmids, minicircles, doggy bones, etc., for use with all major therapeutic vector groups. The Nanoplasmid backbone has profound and unexpected beneficial effects on performance (expression levels and duration). The Nanoplasmid is now available for use in all major viral vector groups...more

 

 

 

 

 

 

 

 

 

 

 

 

HyperGRO Fermentation

Improved DNA manufacturing

 

NTC’s HyperGRO plasmid DNA fermentation process is an advanced, fed-batch, growth restricted process that uses a temperature shift to reach record yields of up to 3.5g/L, a cost-effective path to highly purified, supercoiled DNA that is suitable for use in humans. more....

 

Production of highly-purified research-grade plasmid DNA at NTC’s Lincoln, Nebraska, USA plant range from 1mg to multi-gram scale, and production capabilities for GMP-grade DNA at NTC’s CMO partners range from a hundred milligrams upward.

Small to large scale plasmid DNA production