For many years, Nature Technology Corporation has been a leader in high yield plasmid DNA production, providing the optional process for the manufacturing of your gene-based products, choose from services including: scaled plasmid production (mg to multi-gram); E. coli cell paste; highly enriched for your plasmid (for you to process in-house); to tech transfer (for full in-house production). This uninterrupted chain of process allows you to economically transition from pre-clinical studies, to cGMP, to in-house production in a seamless fashion, without having to ‘re-do’ studies due to process changes.

NTC’s E. coli fermentation process is the most efficient one available in the world today, producing up to 1.5 g/L in fed-batch fermentation. This allows us to beat competitor’s pricing, while providing the highest quality products available.

One secret of NTC’s process is a highly enriched cell paste that serves as the starting point for downstream processing. For example, a culture producing 1,000mg/L requires the processing of only 1/10th as much biomass as a culture producing 100mg/L. Thus, the resulting DNA has to be more pure (see comparison below)

Plasmid DNA for vaccine manufacture: high-yield production and rapid analysis
Nature Technology Corporation, GE Life Sciences

Review Article, Bio Processing
Aaron Carnes B.Sc.Ch., Nature Technology Corporation

An inducible fed-batch fermentation process for scale-up andproduction of DNA vaccines and gene medicines
Aaron Carnes B.Sc.Ch., James Williams Ph.D., and Clague Hodgson Ph.D.
Nature Technology Corporation

Process from Vector Development
to In-house Manufacturing



Vector Design, Construction and Production



Fermentation/Process Development



DNA Manufacturing Outsourcing



Technology Transfer



In-House Manufacturing

Process development at NTC
uses our patent pending fermentation
process and Proprietory HyprerGRO™
media formulations.