NATX Plasmids, for: DNA Vaccines, Gene Therapeutics, Viral Vectors andBiophamacueticals

Process Development
Process from Vector Development to in-House Manufacturing

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NTC's Process from Vector Development to In-house Manufacturing



Vector Design, Construction and Production


Fermentation/Process Development


DNA Manufacturing Outsourcing


Technology Transfer


In-House Manufacturing

For many years, Nature Technology Corporation has been a leader in high yield plasmid DNA production, providing the optimal process for manufacturing gene-based products. Choose from services including: scaled plasmid production (mg to multi-gram); E. coli cell paste, highly enriched for your plasmid (for you to purify); and tech transfer (to CMO, or to your facility for control of production). These alternatives allow you to transition economically from pre-clinical studies, to cGMP, to full-scale production in a seamless fashion, without having to 're-do' studies due to significant process changes.





One secret of NTC's process is the highly-enriched, plasmid-containing cell paste, which serves as the starting point for downstream purification. For example, a culture producing 1,000mg/L or 2,000mg/L requires the processing of only 1/10th or 1/20th as much biomass, respectively, as a culture producing 100mg/L. Thus, the resulting DNA is more pure.

NTC's E. coli fermentation process is the most efficient one available in the world today, producing as much as, or greater than 1-2 g/L in fed-batch fermentation. This allows us to provide you with the most economical pricing, while providing highest quality products.


Process development at NTC uses our patent pending fermentation process and Proprietory HyperGRO media formulations (left).







Review Article, Bio Processing
Aaron Carnes B.Sc.Ch., Nature Technology Corporation

An inducible fed-batch fermentation process for scale-up andproduction of
DNA vaccines and gene medicines

Aaron Carnes B.Sc.Ch., James Williams Ph.D., and Clague Hodgson Ph.D.
Nature Technology Corporation


Plasmid DNA for vaccine manufacture: high-yield production and rapid analysis
Nature Technology Corporation, GE Life Sciences


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