NTC's Process from Vector Development to In-house Manufacturing
Vector Design, Construction and Production
Fermentation/Process Development
DNA Manufacturing Outsourcing
Technology Transfer
In-House Manufacturing
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For many years, Nature Technology Corporation has been a leader in high yield plasmid DNA production, providing the optimal process for manufacturing gene-based products. Choose from services including: scaled plasmid production (mg to multi-gram); E. coli cell paste, highly enriched for your plasmid (for you to purify); and tech transfer (to CMO, or to your facility for control of production). These alternatives allow you to transition economically from pre-clinical studies, to cGMP, to full-scale production in a seamless fashion, without having to 're-do' studies due to significant process changes.
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One secret of NTC's process is the highly-enriched, plasmid-containing cell paste, which serves as the starting point for downstream purification. For example, a culture producing 1,000mg/L or 2,000mg/L requires the processing of only 1/10th or 1/20th as much biomass, respectively, as a culture producing 100mg/L. Thus, the resulting DNA is more pure.
NTC's E. coli fermentation process is the most efficient one available in the world today, producing as much as, or greater than 1-2 g/L in fed-batch fermentation. This allows us to provide you with the most economical pricing, while providing highest quality products.
Process development at NTC uses our patent pending fermentation process and Proprietory HyperGRO™ media formulations (left).
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