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DNA Fermentation Process
HyperGRO™: Licensing
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HyperGRO™ Licensing:
The literature reports plasmid DNA yields in the range of 100-250mg/L for batch and fed-batch fermentations, respectively, vs. 1-20mg/L for shake flask cultures. NTC’s HyperGRO™ technology represents a quantum breakthrough in process efficiency, with typical fed-batch fermentation yields in the 300-2,000mg/L range, and beyond. The patented HyperGRO™ process uses a special animal product free media formulation together with a growth-restricted, temperature-inducible plasmid production phase.
The order-of-magnitude increases in yield translate to dramatic savings and increased purity. HyperGRO™ licensing allows you to move the process into your own facility in order to take full advantage of the cost savings quality. NTC offers both GMP facility licenses (for contract manufacturing) as well as full commercial licenses for in-house production of DNA vaccines and gene therapeutics, as well as other plasmid products.
Pre-license Testing:
Try before you buy. NTC will ferment your plasmid using the HyperGRO™ process in order to determine the actual yield. Cost of proof-of-concept runs is $3,200 each, which includes up to 1g of DNA in the form of cell paste (additional grams for $1,000 each, if available from a 10L fermentor). In this way, you are assured of the actual results with your plasmid before you obtain a license.
Technical Services:
Up to two days of engineer time and one day of regulatory affairs personnel time will be dedicated to the tech transfer, with additional engineering and scientific assistance available. Process development runs at NTC allow rapid yield improvements at low cost.
HyperGRO™ kits:
4L fed-batch fermentation kits are available from NTC for $399 each. Complete instructions, kit license for research use, and tech services by phone are included with the kit.
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HyperGRO™ Kit Terms
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Terms
• Kit purchase includes license for single kit use
• Technology Transfer packages available for CMOs and GMP manufacturing facilities
Applications
• Large scale plasmid DNA manufacturing
• Yield and purity are of utmost importance
• Dramatically lowering production costs
• Significantly increasing production from existing facilities
• Gram to kilogram quantities of DNA are needed
• DNA vaccines
• Gene Therapeutics
• GMP facilities
Supply
The HyperGRO™ animal product free (APF) formulations and non-exclusive license will be provided under confidentiality, along with sample protocols, SOPs, master plans and batch records, ready for implementation in your facility. Up to two days of engineer’s time and one day of regulatory affairs personnel time will be dedicated to the tech transfer, with additional engineering and scientific assistance available.
Contact:
Nature Technology Corp.
4701 Innovation Dr.
Lincoln, NE 68521
(402) 472-6530
www.natx.com
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Contact NTC, Toll free: 1-(888) WIZ-BANG
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