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Proteins
NTC's Rcombinant Protein Production Sevices and Technologies
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Recombinant proteins are rapidly becoming a major industry within biologics, topping $63 billion in 2007 ($39 billion in the U.S. alone), and are anticipated to grow to $87 billion by 2010[i].
NTC is a leading industrial supplier of highest quality, economical, fluorescent recombinant proteins, which are increasingly needed for flow cytometry, confocal microscopy, laser scanning microscopy, immunoconjugates, etc. As more fluorescent proteins are discovered in unique aquatic and rain-forest environments, their uses multiply, making production an art as much as a science.
NTC has devised a unique overall approach to recombinant protein production, which involves careful consideration of design elements and processing steps affecting the product. The result is a superb product: pure, stable, and highly active, manufactured using NTC's pVEX™ E. coli recombinant system (vectors, strains, and processes) .
[i]Daniels, D., (2008) Refining Protein Drug Formulation, Genetic Eng. News 28(16)1-50.
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XXXCase Study: pVEX™: E. coli Protein expression system
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NTC designed marker proteins for diagnostics, including elements for purification and labeling. pVEX™ fermentation and downstream process developed at 2g/L (soluble protein) and transferred to commercial production on behalf of customers.
NTC's production technology pVEX™ (E. coli expression system) combines record breaking yields, careful maturation
ease of chemical conjugation and ultra purification, resulting in the highest quality immunology-grade reagents.
NTC’s pVEX Suite™ is a combination of process, vectors, IP, know-how and trade secrets enabling record yields of 20g/L of recombinant proteins, from E. coli host cells. Obviously, higher yields reduce the cost of goods, increase ROI, and improve final product purity.
pVEX™ fluorescent proteins expressed in a leaky strain illustrate potential 20 g/l production
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XXFluorescent proteins, Biomarkers and Biosensors
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Fluorescent proteins, biomarkers and biosensors have never been hotter. Now, the hottest protein expression system, pVEX™, has been harnessed to create the new intergalactic standard for quality and ingenuity in the maturation and purification of fluorescent chromophores. These are not prepackaged products, but rather are the result of careful design and manufacturing of custom products, ranging from flow cytometry to specialized devices. NTC's process engineers and molecular scientists make the right solutions happen for you in the highest quality immunology-grade reagents.
NTC offers its industry partners a variety of options, including:
• XContract recombinant protein design, development, and production services
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• XLicensing pVEX™ technolgy
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Contact NTC, Toll free: 1-(888) WIZ-Bang
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