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DNA Vaccines: Rapid Development and Rapid Deployment
Providing vaccines in a pandemic timeframe
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NTC's new (2010), rapidly deployable set of DNA vaccination tools can be readily adapted to any antigens in a two-week, "precision cloning" turnaround service, providing vaccines in a pandemic timeframe.
To date, DNA vaccines have shown great promise, and effectiveness in a limited number of animal models. However, they typically lacked the 'quantum leap' in efficacy that is needed for large animal and human use. NTC has now improved the DNA backbone architecture, including:
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Reduced genome (only essential sequences: increases potency, decreases recombination potential) |
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Trafficking (DNA to the nucleus, protein to selected presentation pathways) |
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Optimized expression via transcriptional and translational enhancement and a synthetic intron |
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Antibiotic free (meets regulatory demands) |
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Selected co-stimulators (activates antigen presentation, prevents tolerization) |
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Highest yield in the fermentor (increases purity, cost effectiveness) |
| Six Vector Families Manuals |
| pDNAVACCUltra™ DNA Vaccine Vectors |
| Antibiotic Free, Mammalian Expression and DNA Vaccine Vectors, NTC 8682, NTC 8685 |
| Antibiotic Free, Mammalian Expression and DNA Vaccine Vectors, NTC 8482, NTC 8485 |
| Antibiotic Free, Mammalian Expression and DNA Vaccine Vectors, NTC 8382, NTC 8385 |
KanR, Mammalian Expression Vectors,
NTC 7482, NTC 7485 |
| RIG-I Activating DNA Vaccine Vectors |
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*Save 20% off large scale production cost with NTC’s high-yield, SV40-PAS-BH vectors!
(for a limited time)
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Rapid-VACC™ is streamlined process whereby we provide you with custom-finished DNA vaccine vectors, sequence-validated and ready for animal testing, in record time - a new weapon in the arsenal against infectious diseases, bioterrorism and cancer therapy. Call for more information.
• Rapid assembly of antigens and adjuvant genes into pDNAVaccUltra™ vectors
• Rapid screening of candidate vaccine vectors using Multi-Mode presentation
• Rapid optimization and improvement
• Rapid development of protein boost with pVex™ antigen expression system
High throughput DNA vaccine plasmid generation is a quick, cost effective method for generating intracellular targeted DNA vaccines. In today's world, emerging infectious diseases (like SARS, anthrax, smallpox, West Nile, monkeypox and bird flu ) and bioterrorist threats can appear on our doorstep and spread like wildfire. Now it is possible to create technological weapons against these threats in weeks, instead of months or years.
RapidVACC™ high throughput DNA vaccine plasmid generation is a quick, cost effective process for targeted DNA vaccine vectors. We provide multiple plasmids, each with different destinations, for your gene of interest. Each plasmid utilizes NTC’s proprietary pDNA-VACC-Ultra™ plasmid backbone, optimized for both high level expression of target antigens, appropriate co-stimulatory elements, and for harmonization with FDA points to consider on plasmid DNA vaccines. Immunization with the series of plasmids allows you to rapidly determine the optimal MHC presentation of your protein.
NTC will PCR amplify and clone your gene in pDNAVACC-Ultra™ vaccine expression vector A series using your template and sequence data, sequence insert and ship 4 cell lines to you for in as little as three weeks!
You will receive cell lines* containing your gene in NTC' s pDNAVACC-ultra™.
A1: secreted
A2: membrane anchored
A3: intracellular processing targeted
A4: native
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| Contact NTC, Toll free: 1-(888) WIZ-BANG |
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